C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/22 (2006.01) C07C 331/04 (2006.01) C07D 277/32 (2006.01) C07D 277/34 (2006.01)
Patent
CA 2121488
2121488 9309107 PCTABScor01 The present invention relates to a process for the preparation of compounds of general formula (I), wherein R stands for a straight chained C1-5alkyl group substituted by a chlorine atom in the 2-position, and acid addition salts thereof, characterized by reacting a 3,5-dichloro-2-alkanone of general formula (V), wherein R is a defined above, with an inorganic thiocyanate, and a) converting the 3-thiocyanato-5-chloro-2-alkanone of general formula (IV), thus obtained, wherein R is as defined above, into 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II), wherein R is as defined above, by gaseous hydrochloric acid in an organic solvent, hydrogenating the said compound in the presence of a metal catalyst in an organic solvent, or b) reacting said compound of general formula (IV) with an aqueous mineral acid and treating the 2-hydroxy-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (III), thus obtained with a halogenating agent, and hydrogenating the 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II) thus obtained, wherein R is as defined above, in an organic solvent in presence of a metal catalyst, and optionally converting the 4-methyl-5-(2-chloroalkyl)-thiazole of general formula (I), wherein R is as defined above, thus obtained or a hydrochloride salt thereof, in a manner known per se, into another acid addition salt or setting free a compound of general formula (I), wherein R is a defined above, from its acid addition salt.
Heja Gergely
Korbonits Dezso
Molnar Erzsebet
Palosi Endre
Szvoboda Ida
Astra Aktiebolag
Fetherstonhaugh & Co.
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