4-hydroxythiobenzamide derivatives of drugs

Details 4-hydroxythiobenzamide derivatives of drugs 4-hydroxythiobenzamide derivatives of drugs

C - Chemistry, Metallurgy

07

D

C07D 309/30 (2006.01) C07C 327/48 (2006.01)

Patent

CA 2658429

Derivatives of drugs are provided, said derivatives comprising the H2S-releasing moiety 4-hydroxythiobenzamide that is either covalently linked to the drug or forms a salt with the drug. The compounds of the present invention exhibit enhanced activity or reduced side effects or both.

La présente invention concerne des dérivés de médicaments, lesdits dérivés comprenant la fonction 4-hydroxythiobenzamide, qui libère H2S, ladite fonction se liant par liaison covalente au médicament ou formant un sel avec le médicament. Les composés selon la présente invention présentent une activité améliorée, des effets secondaires réduits ou les deux.

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