C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C07D 239/00 (2006.01)
Patent
CA 2502180
Disclosed are novel pyrimido compounds of the formula (I) wherein R1 to R9 are as defined in the specification, that are selective inhibitors of the Src family of tyrosine kinases. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, hepatic and pancreatic tumors. Also disclosed are pharmaceutical compositions containing these compounds and the use for treating cancer.
La présente invention concerne de nouveaux composés pyrimido représentés par la formule (I) dans laquelle R?1¿ à R?9¿ sont tels que définis dans la description, lesquels composés constituent des inhibiteurs sélectifs de la famille Src des tyrosine kinases. Ces composés et leurs sels pharmaceutiquement acceptables sont des agents anti-prolifératifs utilisés pour traiter ou lutter contre des tumeurs solides, en particulier les tumeurs du sein, les tumeurs du côlon, les tumeurs hépatiques et les tumeurs pancréatiques. Cette invention concerne en outre des compositions pharmaceutiques renfermant ces composés ainsi que leur utilisation pour le traitement du cancer.
Luk Kin-Chun
Rossman Pamela Loreen
Scheiblich Stefan
So Sung-Sau
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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