Substituted benzocycloheptapyridine derivatives useful for...

Details Substituted benzocycloheptapyridine derivatives useful for... Substituted benzocycloheptapyridine derivatives useful for...

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/435 (2006.01) C07D 405/14 (2006.01) C07H 5/06 (2006.01)

Patent

CA 2264513

Novel compounds of formula (1.0) are disclosed. Compounds of formula (1.0) are represented by the compounds of formulas (1.4) or (1.5) wherein R1, R3 and R4 are each independently selected from halo. W represents a group selected from (a), (b), (c) or (d). Also disclosed are methods of inhibiting farnesyl protein transferase and the growth of abnormal cells, such as tumor cells.

L'invention porte sur de nouveaux composés de formule (1.0) représentés par les composés de formules (1.4) et (1.5) dans lesquelles R<1>, R<3> et R<4> sont chacun sélectionnés indépendamment parmi halo, et W représente un groupe sélectionné indépendamment parmi (a), (b), (c) ou (d). L'invention porte également sur des procédés d'inhibition de la farnésyl-protéine transférase, et de la croissance des cellules anormales, par exemple cancéreuses.

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