C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/68 (2006.01)
Patent
CA 2527318
The present invention relates to polynucleotides associated with angiogenesis- related disorders. The present invention also relates to feline angiostatin genes, novel genes associated with angiogenesis-related disorders, such as cancer. The invention encompasses angiostatin nucleic acids, recombinant DNA molecules, cloned genes or degenerate variants thereof, angiostatin gene products and antibodies directed against such gene products, cloning vectors containing mammalian angiostatin gene molecules, and hosts that have been genetically engineered to express such molecules. The invention further relates to methods for the identification of compounds that modulate the expression of angiostatin genes and gene products and to using such compounds as therapeutic agents in the treatment of angiogenesis-related disorders, e.g., cancer. The invention also relates to methods for the diagnostic evaluation, genetic testing and prognosis of angiogenesis-related disorders, e.g., cancer and to methods and compositions for the treatment these disorders.
La présente invention concerne des polynucléotides associés à des troubles liés à l'angiogenèse. L'invention concerne également des gènes d'angiostatine félins, de nouveaux gènes associés à des troubles liés à l'angiogenèse tels que le cancer. L'invention englobe des acides nucléiques d'angiostatine, des molécules d'ADN recombinant, des gènes clonés ou certaines de leurs variantes dégénérées, des produits géniques d'angiostatine et des anticorps dirigés contre ces produits géniques, des vecteurs de clonage contenant des molécules de gènes d'angiostatine de mammifères, et des hôtes issus du génie génétique, capables d'exprimer de telles molécules. L'invention concerne en outre des procédés concourant à l'identification de composés modulant l'expression de gènes d'angiostatine et des produits géniques, et l'utilisation de tels composés comme agents thérapeutiques pour le traitement de troubles liés à l'angiogenèse tels que le cancer. L'invention concerne enfin des procédés destinés à l'évaluation du diagnostic, au test génétique ainsi qu'au pronostic des troubles liés à l'angiogenèse tels que le cancer, et des procédés et compositions destinés au traitement de ces troubles.
Cai Jenny Hong
Tong Xiao
Pfizer Products Inc.
Sim & Mcburney
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