Ergoline derivatives

C - Chemistry – Metallurgy – 07 – D

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167/227, 260/206

C07D 457/06 (2006.01) A61K 31/48 (2006.01)

Patent

CA 2005506

X-7682 Abstract of the Disclosure This invention provides (8.beta.)-N-heteroalkyl-1- alkyl-6-(substituted)ergoline-8-carboxamides useful for blocking 5HT2 receptors in mammals having an excess of serotonin centrally or peripherally. The invention also provides methods for treating sexual dysfunction, hyper- tension, migraine, vasospasm, thrombosis, ischemia, depression, anxiety, sleep disorders and appetite disorders with a compound of the invention.

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