Enteric-coated glucosinolates and beta-thioglucosidases

Details Enteric-coated glucosinolates and beta-thioglucosidases Enteric-coated glucosinolates and beta-thioglucosidases

A - Human Necessities

61

K

A61K 38/47 (2006.01) A61K 9/50 (2006.01) A61K 9/52 (2006.01) A61K 31/375 (2006.01) A61K 31/7028 (2006.01) A61K 36/31 (2006.01)

Patent

CA 2634785

The present invention relates to a particulate composition comprising enteric-- coated glucosinolate and beta-thioglucosidase particles. The present invention further provides a method of converting glucosinolate to isothiocyanate in the small intestine comprising orally administering to a subject an enteric-coated chemoprotectant precursor composition comprising enteric-coated glucosinolate and beta-- thioglucosidase particles. In another aspect, uncoated glucosinolate and beta--thioglucosidase particles may be provided in an enteric-coated capsule. Preferably, the glucosinolate is glucoraphanin and the beta-thioglucosidase is myrosinase. The enteric coating targets the compound for release in the small intestine where beta--thioglucosidase enzyme converts glucosinolate to chemoprotectant isothiocyanate.

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