Thienyl- and furanyl-isoquinolinones and methods for using them

Details Thienyl- and furanyl-isoquinolinones and methods for using them Thienyl- and furanyl-isoquinolinones and methods for using them

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/4741 (2006.01) A61K 31/4743 (2006.01) A61K 31/5377 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 491/048 (2006.01)

Patent

CA 2728466

The present invention relates to substituted thienyl- and furanyl- isoquinolinones that act, for example, as modulators of poly(ADP-ribose) polymerase (PARP). The present invention also relates to processes for the preparation of substituted thienyl and furanyl-isoquinolinones and to their use in treating various diseases and disorders.

L'invention concerne des thiényl-isoquinolinones substituées et des furanyl-isoquinolinones substituées, qui servent, par exemple, de modulateurs de la poly(ADP-ribose) polymérase (PARP). L'invention concerne également des procédés de préparation de thiényl-isoquinolinones substituées et de furanyl-isoquinolinones substituées, et leur utilisation pour traiter des maladies et des troubles variés.

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