Parallel high-performance liquid chromatography with serial...

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G01N 30/22 (2006.01) G01N 30/46 (2006.01) G01N 30/02 (2006.01) G01N 30/16 (2006.01) G01N 30/24 (2006.01) G01N 30/62 (2006.01) G01N 30/88 (2006.01)

Patent

CA 2321376

High-performance liquid chromatography (HPLC) methods and systems are disclosed that combine sequential, serial injection of a plurality of samples into mobile-phases supplied in parallel to two or more chromatographic columns, such that staggered, parallel separation of the plurality of samples is effected. Because injection of samples is relatively fast as compared to separation, substantial efficiencies are gained with respect to overall sample throughput. The disclosed HPLC methods and systems are preferably applied in connection with combinatorial chemistry, combinatorial material science and more particularly, combinatorial synthesis and screening of polymeric materials

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