Pharmaceutical compositions having depigmentating and...

Details Pharmaceutical compositions having depigmentating and... Pharmaceutical compositions having depigmentating and...

A - Human Necessities

61

K

167/310

A61K 8/362 (2006.01) A61K 8/67 (2006.01) A61K 31/20 (2006.01) A61Q 19/02 (2006.01) A61Q 19/08 (2006.01)

Patent

CA 2036678

11 Abstract PHARMACEUTICAL COMPOSITIONS HAVING DEPIGMENTATING AND ANTIPHOTOAGEING ACTIVITY The object of the present invention is a product based on a trans-retinoic acid (tretinoin) and azelaic acid combination having depigmentating effect and, more generally, antiphotoageing effect. After clinical and instrumental comparative analysis (clinical and photographic reports and skin mould profilometry), the action on physiological and/or photoinduced skin ageing obtained with the combination of the invention has been compared with the one noticeable after the treatment with azelaic acid or retinoic acid only. Better results were obtained using the azelaic-retinoic combination. The depigmentating action of the combination is superimposable to the one observed by using separately the two active ingredients, but it can be achieved in a surprisingly shorter time (from six to three months).

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