Piperazino derivatives as neurokinin antagonists

Details Piperazino derivatives as neurokinin antagonists Piperazino derivatives as neurokinin antagonists

C - Chemistry, Metallurgy

07

D

C07D 487/08 (2006.01) C07D 471/08 (2006.01) A61K 31/496 (2006.01) A61K 31/4995 (2006.01)

Patent

CA 2317760

The invention relates to neurokinin antagonists of formula (I) wherein Z, Rc, y, m, u, Ar2, n, X, Rc', I and Ar2 are as described herein. These compounds are useful in the treatment of diseases such as asthma, anxiety, depression, emesis and nociception.

L'invention concerne des antagonistes de la neurokinine de la formule (I) dans laquelle Z, R¿c?, y, m, u, Ar¿2?, n, X, R¿c'?, I et Ar¿2? sont tels que décrits dans le mémorandum descriptif. Ces composés sont efficaces dans le traitement de maladies telles que l'asthme, l'anxiété, la dépression, le vomissement et la nociception.

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