Method for making pharmaceutical compounds

C - Chemistry – Metallurgy – 07 – C

Patent

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C07C 209/00 (2006.01) C07C 227/16 (2006.01) C07C 231/12 (2006.01) C07D 263/22 (2006.01)

Patent

CA 2744198

A method of making a phenylethylamine of formula (B): wherein R2, R3, R4, R5, R6, R.alpha., R.beta. and R n are each independently selected from hydrogen, alkyl, acyl, aryl, amido, amino acids, sugars and nucleotides. The method includes the reduction of a compound of formula (A) in the absence of base: wherein R2, R3, R4, R5, R6, R.alpha., R.beta. and R n are as defined above.

L'invention porte sur un procédé de fabrication d'une phényléthylamine de formule (B) : dans laquelle R2, R3, R4, R5, R6, Ra, Rß et Rn sont chacun indépendamment choisis parmi un atome dhydrogène, des groupes alkyle, acyle, aryle, amido, des acides aminés, des sucres et des nucléotides. Le procédé comprend la réduction d'un composé de formule (A) en l'absence d'une base : dans laquelle R2, R3, R4, R5, R6, Ra, Rß et Rn sont tels que définis ci-dessus.

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