Modified hvi-type hirudin and process for the manufacture...

Details Modified hvi-type hirudin and process for the manufacture... Modified hvi-type hirudin and process for the manufacture...

C - Chemistry, Metallurgy

12

N

530/7.1, 195/1.2

C12N 15/75 (2006.01) C07K 14/815 (2006.01) C12N 9/54 (2006.01) C12N 15/15 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01) F02B 1/04 (2006.01)

Patent

CA 2018211

Modified HV1 -type hirudin in which valine at the N-terminal end of the HV1-type hirudin and aspartic acid at the 5th residue of the N-terminal end were replaced with alanine and glutamic acid, respectively. A secretion plasmid into which a DNA sequence coding for a precursor with an addition of a secretion signal of neutral protease of Bacillus amyloliquifacience at the N-terminal end of this modified HV1-type hirudin is integrated is introduced into bacteria of the genus Bacillus and the precursor is expressed intracellularly. The modified HV1-type hirudin can be efficiently secreted extracellularly while maintaining its high thrombin inhibiting activity.

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