Use of mixtures of active substances, containing...

Details Use of mixtures of active substances, containing... Use of mixtures of active substances, containing...

A - Human Necessities

61

K

A61K 31/575 (2006.01) A61K 9/48 (2006.01) A61K 31/7088 (2006.01) A61K 31/722 (2006.01) A61P 3/06 (2006.01)

Patent

CA 2273341

In order to produce hypocholesteremic agents, mixtures of active substances containing (a) phytostenols and/or phytostenol esters and (b) potentiators, selected from the group which is formed by chitosans, phytostenol sulfates and/or (desoxy)-ribonucleic acids are used. Although the potentiators per se have no or only a slight hypocholesteremic effect, they increase the speed at which the phytostenol esters lower the cholesterol content in serum. By encapsulating the agents in gelatin, said agents can even be administered orally in high doses without any problems occurring.

Il est proposé, selon l'invention, pour produire des agents hypocholestérolémiants, d'utiliser des mélanges de principes actifs contenant (a) des phytosténols et/ou des esters de phytosténol et (b) des agents de potentialisation choisis dans le groupe comprenant des chitosanes, des sulfates de phytosténol et/ou des acides (désoxy)ribonucléiques. Bien que les agents de potentialisation n'aient eux-mêmes qu'un faible effet hypocholestérolémiant, voire aucun, ils augmentent la vitesse à laquelle les esters de phytosténol font baisser la teneur en cholestérol du sérum. Grâce à leur encapsulation dans de la gélatine, ces agents peuvent être administrés sans problèmes, même par voie orale, en doses élevées.

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