Treatment of female sexual dysfunction

Details Treatment of female sexual dysfunction Treatment of female sexual dysfunction

A - Human Necessities

61

K

A61K 31/473 (2006.01) A61P 15/12 (2006.01) A61K 31/485 (2006.01)

Patent

CA 2322289

Sexual dysfunction in human females can be ameliorated, without substantial undesirable side effects, by sublingual administration of apomorphine dosage forms. Administration of apomorphine increases nerve stimulated clitoral intracavernosal blood flow and vaginal wall blood flow for enhanced clitoral erection and vaginal engorgement in a female. A plasma concentration of apomorphine of no more than about 5.5 nanograms per milliliter is preferably maintained.

La dysfonction sexuelle chez la femme peut être améliorée, sans effets secondaires indésirables importants, par administration sublinguale de formes posologiques de l'apomorphine. L'administration d'apomorphine augmente l'écoulement sanguin intracaverneux stimulé par les nerfs dans le clitoris et l'écoulement sanguin dans la paroi vaginale, ce qui provoque chez la femme une érection clitoridienne et un engorgement vaginal améliorés. On maintient, de préférence, une concentration de l'apomorphine dans le plasma n'excédant pas environ 5,5 nanogrammes par millimètre.

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