Prostaglandin e2 binding proteins and uses thereof

Details Prostaglandin e2 binding proteins and uses thereof Prostaglandin e2 binding proteins and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 39/395 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2728909

The present invention encompasses prostaglandin E2 (PGE2) binding proteins. The invention relates to antibodies that are wild-type, chimeric, CDR grafted and humanized. Preferred antibodies have high affinity for prostaglandin E2 and neutralize prostaglandin E2 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody, or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antigen-binding portions, of the invention are useful for detecting prostaglandin E2 and for inhibiting prostaglandin E2 activity, e.g., in a human subject suffering from a disorder in which prostaglandin E2 activity is detrimental.

La présente invention porte sur des protéines de liaison à la prostaglandine E2 (PGE2). L'invention porte sur des anticorps qui sont de type sauvage, chimériques, CDR-greffés et humanisés. Les anticorps préférés ont une affinité élevée pour la prostaglandine E2 et neutralisent l'activité de prostaglandine E2 in vitro et in vivo. Un anticorps de l'invention peut être un anticorps de longueur entière, ou une partie de liaison à l'antigène de celui-ci. L'invention porte également sur des procédés de fabrication et des procédés d'utilisation des anticorps de l'invention. Les anticorps, ou domaines de liaison à l'antigène, de l'invention sont utiles pour détecter la prostaglandine E2 et pour inhiber l'activité de prostaglandine E2, par exemple, chez un sujet humain souffrant d'un trouble dans lequel l'activité de la prostaglandine E2 est préjudiciable.

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