A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 49/00 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 9/51 (2006.01) A61K 33/26 (2006.01) A61K 49/18 (2006.01) B01J 13/02 (2006.01)
Patent
CA 2195318
A nanoparticle compound is provided herein for use in diagnosis and therapy. The nanoparticle compound is an iron-containing core comprising iron material, namely magnetite or maghemite. A synthesis polymer coats the iron-containing core, the synthesis polymer being a dextran or a derivative of dextran. A targeting polymer is non-covalently bonded to, and envelopes, the synthesis polymer to form a second coating. In this way, the targeting polymer is not exposed to synthesis conditions.
L'invention concerne des nanoparticules à structure modulaire contenant du fer, leur préparation et leur utilisation en diagnostic et thérapie. Ces nanoparticules se caractérisent en ce qu'elles comprennent un noyau contenant du fer, une couche primaire d'enrobage (polymère de synthèse) et une couche secondaire d'enrobage (polymère cible), et le cas échéant des substances auxiliaires pharmaceutiques, des préparations pharmaceutiques et/ou des médiateurs d'adsorption.
Ebert Wolfgang
Elste Volker
Gaida Josef
Herrmann Anja
Jukl Monika
Borden Ladner Gervais Llp
Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat
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