Use of a retinoid type compound to modulate in vivo the...

Details Use of a retinoid type compound to modulate in vivo the... Use of a retinoid type compound to modulate in vivo the...

A - Human Necessities

61

K

A61K 31/20 (2006.01) A61K 31/203 (2006.01)

Patent

CA 2299270

This invention relates to the use of a compound of the retinoïd type particularly retinoïc acid for the preparation of a medicament capable of modulating in vivo the decoupling activity of decoupling proteins. These compounds can be used conveniently for the treatment of diseases associated to an increase or reduction of the activity of decoupling proteins. According to a preferred embodiment, the retinoïc acid will be used for the treatment of diseases associated to a reduction of the decoupling activity of the protein UCP2 such as for example obesity.

La présente invention concerne l'utilisation d'un composé de type rétinoïde, et plus particulièrement, de l'acide rétinoïque, utilisé pour préparer un médicament permettant de moduler l'activité des protéines de désaccouplement. Ces composés peuvent être utilisés, de manière avantageuse, pour traiter les maladies associées à une augmentation ou une diminution de l'activité des protéines de désaccouplement. Selon un mode de réalisation préféré, l'acide rétinoïque est utilisé pour traiter les maladies associées à une diminution de l'activité de désaccouplement de la protéine UCP2 comme, par exemple, l'obésité.

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