C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 317/32 (2006.01) A61K 31/145 (2006.01) A61K 31/155 (2006.01) A61K 31/165 (2006.01) A61K 31/17 (2006.01) A61K 31/18 (2006.01) A61K 31/4168 (2006.01) A61K 31/505 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01) A61P 25/28 (2006.01) C07D 233/48 (2006.01) C07D 233/88 (2006.01) C07D 239/14 (2006.01)
Patent
CA 2654822
The application relates to compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein: m is, from 0 to 3; q is from 0 to 3; Ar is optionally substituted aryl or optionally substituted heteroaryl; R1 and R7 each independently is halo, allkyl, haloalkyl, alkoxy, hydroxy,heteroalkyl, cyano,-S(O)-Ra,-C(=O)-NRbRC,-SO2-NRbRc,-N(Rd)-C(=O)-Re, or -C(=O)-Rf, where t is from 0 to i Ra, Rb, Rc, Rd and Re each independently is hydrogen or alkyl, and Rf is hydrogen, alkyl, alkoxy or hydroxy; (II), n is from 1 to 3; The compounds are 5-Hydroxytryptamine 6 and 2A receptor modulators. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I.
L'invention concerne des composés de formule (I) ou des sels pharmaceutiquement acceptables de ces composés, m, q, Ar, R1, R2 et R7 étant tels que définis dans la description. L'invention concerne également des procédés de préparation des composés de formule (I), des procédés visant à utiliser de tels composés ainsi que des compositions les comprenant.
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
LandOfFree
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