N-but-3-enyl norbuprenorphine and its use as analgesic

Details N-but-3-enyl norbuprenorphine and its use as analgesic N-but-3-enyl norbuprenorphine and its use as analgesic

C - Chemistry, Metallurgy

07

D

C07D 489/12 (2006.01) A61K 31/485 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2439859

The present invention provides compound having the structure: and pharmaceutically acceptable salts or derivatives thereof, as well as compositions including such compounds. The invention also provides methods of (1) preventing pain, (2) treating pain, (3) inducing sedation, (4) treating opiate addiction, (5) treating opiate withdrawal (abstinence syndrome) and/or (6) treating cough in a patient in need thereof by administering a compound or composition of the invention.

L'invention concerne un composé présentant la structure: [structure] et des sels ou des dérivés pharmaceutiquement acceptables de celui-ci, ainsi que des compositions contenant ces composés. L'invention concerne en outre des méthodes (1) de prévention de la douleur, (2) de traitement de la douleur, (3) de sédation, (4) de traitement de la toxicomanie opiacée, (4) de traitement de sevrage de la dépendance aux opiacés (syndrome de manque) et/ou (6) de traitement de la toux chez un patient nécessitant un tel traitement, qui comprennent l'administration d'un composé ou d'une composition décrits.

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