A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/445 (2006.01) A61K 31/4468 (2006.01)
Patent
CA 2338465
Compositions employing and methods utilizing the optically pure (+) isomer of norcisapride are disclosed. This compound has surprisingly been found to be a potent drug for the treatment of disorders of the central nervous system. The compound, (+) norcisapride, has also been found to be a potent antiemetic agent. Finally, the (+) isomer of norcisapride also avoids certain adverse side effects and certain adverse drug interactions. The compound is further useful for treating gastro-intestinal motility dysfunction, gastro-esophageal reflux disease, dyspepsia, gastroparesis, intestinal pseudo-obstruction. It has a prokinetic effect.
La présente invention concerne, d'une part des compositions employant l'isomère (+) optiquement pur du norcisapride, et d'autre part les traitements correspondants. Ce composé s'est révélé être un médicament puissant pour le traitement de troubles du système nerveux central. Ce composé, le norcisapride (+), s'est révélé être un antiémétique puissant. Enfin, l'isomère (+) du norcisapride permet d'éviter certains effets secondaires et certaines interactions médicamenteuses indésirables. Ce composé convient en outre pour traiter des dysfonctions de la motilité gastro-intestinale, le reflux gastro-oesophagien, la dyspepsie, gastroparésie et la pseudo-obstruction intestinale. C'est en outre un stimulant de la motilité gastrique.
Jerussi Thomas P.
Mccullough John R.
Osler Hoskin & Harcourt Llp
Sepracor Inc.
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