Chemical synthesis of reagents for peptide coupling

Details Chemical synthesis of reagents for peptide coupling Chemical synthesis of reagents for peptide coupling

C - Chemistry, Metallurgy

07

F

C07F 5/02 (2006.01) C07F 9/50 (2006.01) C07K 1/00 (2006.01) C07K 2/00 (2006.01) C07K 5/06 (2006.01) C07K 14/00 (2006.01) C07K 17/00 (2006.01)

Patent

CA 2489186

The present invention provides improved methods for synthesis of phosphinothiol reagents, as well as novel protected reagents, for use in formation of amide bonds, and particularly for peptide ligation. The invention provides phosphineborane complexes useful as reagents in the formation of amide bonds, particularly for the formation of an amide bond between any two of an amino acid, a peptide, or a protein.

L'invention concerne des procédés perfectionnés de synthèse de réactifs phosphinothiol, ainsi que de nouveaux réactifs protégés, utilisés pour la formation de liaisons amide et en particulier pour une liaison peptidique. Cette invention concerne des complexes phosphine-borane utilisés comme réactifs dans la formation de liaisons amide, en particulier pour la formation d'une liaison amide entre deux éléments choisis parmi un acide aminé, un peptide et une protéine.

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