Biologically active and particularly peptide molecules...

Details Biologically active and particularly peptide molecules... Biologically active and particularly peptide molecules...

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A23K 1/165 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) A61K 38/27 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 7/06 (2006.01) C07K 14/61 (2006.01) C07K 17/00 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2243845

A peptide construct including all or part of the sequence between positions 104 and 113 of growth hormone GH, or a homologous sequence cross-reactive therewith, is disclosed. The peptide fragment is covalently bonded to a transporter peptide and/or an adjuvant, and is capable of having an in vivo potentiating effect on the biological activity of said growth hormone.

La présente invention concerne une construction peptidique comprenant toute ou partie de la séquence allant de la position 104 à 113 de l'hormone de croissance GH ou d'une séquence homologue présentant une immunoréactivité croisée avec ladite séquence, ledit fragment peptidique étant lié de façon covalente à un peptide transporteur et/ou un adjuvant, et étant capable d'induire in vivo un effet potentialisateur de l'activité biologique de ladite hormone de croissance.

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