Stabilization of the enzyme urate oxidase in liquid form

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 9/06 (2006.01) C12N 9/96 (2006.01) C12Q 1/28 (2006.01) C12Q 1/62 (2006.01)

Patent

CA 2068496

ABSTRACT This invention relates to a process for stabilizing the enzyme urate oxidase (commonly known as uricase) in liquid form, and to the relative compositions which can then be obtained, with particular reference to compositions containing a Trinder reagent. According to the process of the invention, uricase can be stabilized in liquid form by adding to the composition containing the enzyme a substituted or unsubstituted dicarboxylic acid containing from 2 to i carbon atoms, and preferably 4 or 5. Aspartic acid has shown to be particularly effective in providing said stabilizing activity in liquid uricase compositions containing a Trinder reagent.

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