Method of using neurotrophic carbamates and ureas

Details Method of using neurotrophic carbamates and ureas Method of using neurotrophic carbamates and ureas

A - Human Necessities

61

K

A61K 31/34 (2006.01) A61K 31/4439 (2006.01) A61K 31/535 (2006.01)

Patent

CA 2281096

This invention relates to a method of using neurotrophic low molecular weight, small molecule carbamates and ureas having an affinity for FKBP-type immunophilins, as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.

Cette invention concerne une méthode d'utilisation de carbamates et d'urées de faible masse moléculaire, à petites molécules, présentant une affinité pour les immunophilines de type FKBP, en tant qu'inhibiteurs de l'activité enzymatique associée à des protéines d'immunophiline, notamment l'activité enzymatique de peptidyl-prolyle isomérase ou rotamase.

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