1h-imidazopyridine derivatives

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 3/10 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2399136

1H-Imidazopyridine derivatives represented by the following general formula (I) or salts thereof which have an effect of inhibiting cytokine production: (I) wherein R1 represents hydrogen, alkyl, cycloalkyl or aryl; R2 represents cycloalkyl, alkyl, aryl, cyano, mercapto, carboxy or carbamoyl; the ring A represents a homocycle or a heterocycle; R3 represents amino or a saturated nitrogen-containing heterocycle; and k is an integer of 0 to 3, provided that the case where R3 is a saturated nitrogen-containing heterocycle and R2 is unsubstituted alkyl is excluded.

L'invention concerne des dérivés de 1H-imidazopyridine représentés par la formule générale (I) ou leurs sels présentant l'effet d'inhiber la production de cytokine, formule dans laquelle R?1¿ représente hydrogène, alkyle, cycloalkyle ou aryle; R?2¿ représente cycloalkyle, alkyle, aryle, cyano, mercapto, carboxy ou carbamoyle; le cycle A représente un homocycle ou un hétérocycle; R?3¿ représente amino ou un hétérocycle contenant un azote saturé; et k représente un nombre entier de 0 à 3, à condition que soit exclu le cas où R?3¿ représente un hétérocycle contenant un azote saturé et R?2¿ représente alkyle non substitué.

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