Methods for producing antigen-specific, high-affinity human...

Details Methods for producing antigen-specific, high-affinity human... Methods for producing antigen-specific, high-affinity human...

C - Chemistry, Metallurgy

12

N

C12N 5/24 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C07K 16/42 (2006.01) C07K 19/00 (2006.01) C12N 5/16 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2082041

2082041 9117769 PCTABS00008 The present invention relates to advances in monoclonal antibody production, and particularly, in culturing methodology preparatory to hybridoma formation. Specifically, retention of lymphoid fragments in the culture systems results in predominantly IgG-secreting, long-lived cultures.

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