C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/56 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2561621
Quinolone carboxylic acid derivatives of formula (I) wherein Ar is an optionally substituted phenyl, pyridyl, or pyrimidinyl group and the substituent groups R1, R4, R10, R11, R19, and R20 are as defined in the specification, pharmaceutical compositions containing them, and methods of using them in treatment of hyperproliferative diseases such as cancer are disclosed and claimed.
Cette invention concerne et revendique des dérivés d'acide carboxylique de quinolone représentés par la formule (I), dans laquelle Ar représente un groupe phényle, pyridyle ou pyrimidinyle éventuellement substitué et les groupes substituants R?1¿, R?4¿, R?10¿, R?11¿, R?19¿ et R?20¿ sont tels que définis dans les pièces descriptives de la demande, des compositions pharmaceutiques contenant ces dérivés, et des procédés d'utilisation de ces dérivés dans le traitement des maladies hyperprolifératives, telles que le cancer.
Guernon Leatte
Khire Uday
Liu Donglei
Liu Xiao-Gao
Nagarathnam Dhanapalan
Bayer Pharmaceuticals Corporation
Borden Ladner Gervais Llp
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