Imidazole compounds as anti-inflammatory and analgesic agents

Details Imidazole compounds as anti-inflammatory and analgesic agents Imidazole compounds as anti-inflammatory and analgesic agents

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) A61K 31/4164 (2006.01) A61K 31/4168 (2006.01) A61K 31/4184 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61P 29/00 (2006.01) C07D 233/54 (2006.01) C07D 233/88 (2006.01) C07D 235/08 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2481532

This invention provides a compound of the formula (1) wherein: R1 represents a hydrogen atom, an alkyl group, etc.; R2 represents a hydrogen atom, a halogen atom, etc.; R3 represents a hydrogen atom, an alkyl group, etc.; R4 represents an aryl group, etc.; A represents an aryl1, etc; B represents an alkylene etc.; X represents NH, etc.; or a phannaceutically acceptable ester of such compound, and pharmaceutically acceptable salts thereof. These compounds are useful for the treatment of medical conditions mediated by prostaglandins such as pain, fever or inflammation, etc. This invention also provides a pharmaceutical composition comprising the above compound.

L'invention concerne un composé représenté par la formule (I) dans laquelle R?1¿ est un atome d'hydrogène, un groupe alkyl etc., R?2¿ est un atome d'hydrogène, un atome halogène etc., R?3¿ est un atome d'hydrogène, un groupe alkyl etc., R?4¿ est un groupe aryl etc., A est un aryl?1¿ etc., B est un alkylène etc., et X est NH etc., ou un ester pharmaceutiquement acceptable d'un tel composé et des sels pharmaceutiquement acceptables dudit composé ou ester. Les composés selon l'invention servent au traitement de troubles médicaux à médiation par prostaglandine, tels que la douleur, la fièvre ou les inflammations. L'invention concerne également une composition pharmaceutique contenant lesdits composés.

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