Effervescent microspheres and method for making them

Details Effervescent microspheres and method for making them Effervescent microspheres and method for making them

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 9/46 (2006.01) A61K 9/50 (2006.01)

Patent

CA 2278651

The invention concerns multilayer microspheres containing an acid substance, a basic substance and a water-soluble isolating agent which when it dissolves in water, after almost instant effervescence, brings about a homogeneous dispersion of the active principle. The invention also concerns a method for preparing such microspheres by rotational granulation on a fluid air bed associated with a system of tangential spraying of the wetting liquid.

La présente invention concerne des microsphères multicouches renfermant une substance acide, une substance basique et un agent isolant hydrosoluble dont la dissolution dans l'eau conduit, après effervescence quasi instantanée, à une solution ou une dispersion homogène de principe actif. La présente invention concerne également un procédé de préparation de telles microsphères par la méthode de rotogranulation en lit d'air fluidisé associée à un système de pulvérisation tangentielle du liquide de mouillage.

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