Substituted aryl cycloalkanol derivatives and methods of...

C - Chemistry – Metallurgy – 07 – D

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C07D 295/092 (2006.01) A61K 31/496 (2006.01) C07D 243/08 (2006.01)

Patent

CA 2540207

The present invention is directed to substituted aryl cycloalkanoyl derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia,vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

L'invention concerne des dérivés de cycloalcanoyl aryle substitués, des compositions contenant ces dérivés ainsi que des procédés d'utilisation de ceux-ci pour la prévention et le traitement d'états pathologiques améliorés par réabsorption de monoamine, notamment symptômes vasomoteurs (VMS), dysfonctionnement sexuel, troubles gastro-intestinaux et génito-urinaires, syndrome de fatigue chronique, syndrome de fibromyalgie, troubles du système nerveux et combinaisons de ceux-ci, et plus spécifiquement d'états pathologiques choisis dans le groupe comprenant trouble dépressif majeur, symptômes vasomoteurs, incontinence par impétuosité et par stress, fibromyalgie, douleur, neuropathie diabétique et combinaisons de ceux-ci.

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