Fluorescent dyes for probes for analysis of nucleic acids

Details Fluorescent dyes for probes for analysis of nucleic acids Fluorescent dyes for probes for analysis of nucleic acids

C - Chemistry, Metallurgy

09

B

C09B 23/01 (2006.01) C07H 21/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2451442

Disclosed are compounds with the chemical structure: (see formula I), (see formula II), (see formula III), where R1 is a hydrogen or to the nitrogen non-conjugated alkyl group of at most 6 carbon atoms, that may be substituted as specified below, where X is O, S, Se, N-R5, where R5 is a hydrogen or an alkyl group that may be substituted as specified below, or CR6R7, where R6 and R7, which may be same, are hydrogens or alkyl groups, that may be substituted as specified below, where R2, R3 and R4, of which two or all three may be same, are hydrogen, small alkyl groups, that may be substituted as specified below, aryles, or in pair, R2 and R4 or R3 and R4, and in combination with two of the ring atoms, make a 5 or 6-membered aromatic ring, that may contain 0-2 heteroatoms such as O, S and N-R8 , where R8 is a hydrogen or an alkyl group, that may be substituted as specified below, where n = 0, 1 or 2, where Y is HC=CH, and A and B are both 0 or 1; if A=0 then B=1 and vice versa, where R9 and R10, which may be same, are hydrogens or to the nitrogen non- conjugated alkyl groups, that maybe substituted as specified below, and R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are hydrocarbon chain, that may have polar residues such as hydroxyl groups, alkoxy groups, carboxyl groups or amino groups, and contain stiff, charged or bulky groups, and one of them has a isothiocyanine, imidyl, sulfonyl chloride or carbonyl group that is separated by at least one spa-hybridized carbon from the aromatic system, and R1, R2, R3, R4, R5, R6, R7, R8,R9 and R10 are hydrocarbon chain, that may have polar residues, such as hydroxyl groups, alkoxy groups, carboxyl groups and amino groups, and one of them has a carboxylic acid group that is separated by at least one spa-hybridized carbon from the aromatic system.

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