Acid derivatives useful as serine protease inhibitors

Details Acid derivatives useful as serine protease inhibitors Acid derivatives useful as serine protease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/343 (2006.01) A61K 31/437 (2006.01) A61K 31/44 (2006.01) A61K 31/444 (2006.01) A61K 45/06 (2006.01) A61P 7/02 (2006.01) C07C 237/52 (2006.01) C07C 257/18 (2006.01) C07D 207/16 (2006.01) C07D 209/08 (2006.01) C07D 211/34 (2006.01) C07D 211/60 (2006.01) C07D 213/73 (2006.01) C07D 213/81 (2006.01) C07D 221/00 (2006.01) C07D 223/06 (2006.01) C07D 235/00 (2006.01) C07D 235/30 (2006.01) C07D 261/08 (2006.01) C07D 261/20 (2006.01) C07D 275/04 (2006.01) C07D 307/79 (2006.01) C07D 401/0

Patent

CA 2428191

Compounds having the formula (I), are useful as serine protease inhibitors, more particularly inhibitors of Factors VIIa, Ixa, Xa, and/or Xia, wherein ring B is phenyl or pyridyl, W is preferably C(=O)NR4R5, L is a linker group, X2 comprises nitrogen or carbon, Z is an optionally-substituted monocyclic or bicyclic ring system, and R1, R2, R3, R4, R5 and R6 are as defined in the specification.

L'invention concerne des composés de formule (I) utiles comme inhibiteurs de sérines protéases, et plus particulièrement comme inhibiteurs des facteurs VIIa, IXa, Xa et/ou XIa. Dans cette formule, le noyau B est phényle ou pyridyle, W est de préférence C(=O)NR¿4?R¿5?, L est un groupe de liaison, X¿2? comprend de l'azote ou du carbone, Z est un système de noyau bicyclique ou monocyclique éventuellement substitué, et R¿1?, R¿2?, R¿3?, R¿4?, R¿5? et R¿6? sont tels que définis dans la description.

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