Use of .delta.5 androstenes in the treatment of hiv wasting...

A - Human Necessities – 61 – K

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A61K 31/56 (2006.01)

Patent

CA 2276783

HIV-related weight loss, HIV-related cachexia and HIV-related wasting syndrome can be treated by administering therapeutic amounts of the steroid .DELTA.5- androstene-3.beta.-ol-7,17 dione and metabolizable precursors thereof, such as .DELTA.5-androstene-3.beta.-acetoxy-7,17 dione, which are readily metabolized in vivo to .DELTA.5-androstene-3.beta.-ol-7,17 dione. Such treatment can be prophylactic, modulatory, ameliorative or curative in nature.

On peut traiter la perte de poids liée au VIH, la cachexie liée au VIH et le syndrome de dépérissement lié au VIH en administrant des doses thérapeutiques du stéroïde .DELTA.5-androstène-3.beta.-ol-7,17 dione et de ses précurseurs métabolisables tels que le .DELTA.5-androstène-3.beta.-acétoxy-7,17 dione, lesquels sont rapidement métabolisés in vivo en .DELTA.5-androstène-3.beta.-ol-7,17 dione. Ce traitement peut être d'ordre prophylactique, modulateur, amélioratif ou curatif.

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