C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/82 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2217668
Specific BRCA1 mutations, PCR primers and hybridization probes are used in nucleic acid-based methods for diagnostic of inheritable breast cancer susceptibility. Addtionally, binding agents, such as antibodies, specific for peptides encoded by the subject BRCA1 mutants are used to identify expression products of diagnostic mutations/rare alleles in patient derived fluid or tissue samples. Compositions with high binding affinity for transcription or translation products of the disclosed BRCA1 mutations and alleles are used in therapeutic intervention. Such products include anti-sense nucleic acids, peptides encoded by the subject nucleic acids, and binding agents such as antibodies, specific for such peptides.
On utilise des mutations spécifiques du locus BRCA1, des amorces PCR et des sondes d'hybridation dans des procédés recourant à des acides nucléiques pour diagnostiquer les prédispositions héréditaires au cancer du sein, ains que des agents de liaison, tels que des anticorps, spécifiques de peptides codés par lesdits mutants de BRCA1 pour identifier les produits d'expression d'allèles mutants ou rares de diagnostic dans des prélèvements de liquides ou de tissus provenant du patient. Des compositions à forte affinité pour les produits de transcription ou de translation des mutations ou allèles du locus BRCA1 selon l'invention peuvent être utilisées dans des interventions thérapeutiques. Ces produits comprennent des acides nucléiques anti-sens, des peptides codés par les susdits acides nucléiques et des agents de liaison tels que des anticorps spécifiques de ces peptides.
Friedman Lori
King Mary-Claire
Lee Ming
Lynch Eric
Ostermeyer Beth
Smart & Biggar
The Regents Of The University Of California
LandOfFree
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