Immortalized hematopoietic cell lines, cell system thereof...

Details Immortalized hematopoietic cell lines, cell system thereof... Immortalized hematopoietic cell lines, cell system thereof...

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A61K 35/28 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) C12N 5/10 (2006.01) C12N 15/87 (2006.01) C12Q 1/18 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2248555

Extented life hematopoietic cell lines include stromal cell lines useful for the in vitro maintenance of undifferentiated pluripotent hematopoietic stem cells. Undifferentiated and differentiated immortalized stem cells are suitable for bone marrow transplantation, gene therapy and cell therapy applications, and as an in vitro model system for drug discovery and toxicological testing.

Cette invention concerne des lignées cellulaires hématopoïétiques ayant une durée de vie plus longue, notamment des lignées cellulaires du stroma utiles dans la conservation in vitro de cellules souches hématopoïétiques pluripotentielles non différentiées. Les cellules souches immortalisées différentiées et non différentiées peuvent être utilisées dans la transplantation de moelle osseuse, dans des applications de thérapie génique et de thérapie cellulaire, ainsi que dans des systèmes de modèles in vitro afin de découvrir des médicaments ou d'effectuer des analyses toxicologiques.

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