Stable non-dihydrate azithromycin oral suspensions

Details Stable non-dihydrate azithromycin oral suspensions Stable non-dihydrate azithromycin oral suspensions

A - Human Necessities

61

K

A61K 31/7052 (2006.01) A61K 9/00 (2006.01) A61K 31/7048 (2006.01) A61K 47/30 (2006.01)

Patent

CA 2464831

This invention relates to a powder for oral suspension, and an oral suspension made there from, which comprises non-dehydrate azithromycin and an azithromycin conversion stabilizing excipient, wherein said excipient reduces the conversion of the form of azithromycin, when placed in suspension, to another form of azithromycin. This invention further relates to a method for reducing the conversion of a form of non-dehydrate azithromycin, in an oral suspension, by adding a surface tension reducing excipient that reduces the surface tension of the aqueous vehicle. Furthermore, this invention relates to a method for reducing the conversion of a non-dehydrate azithromycin, in an unflavored oral suspension, by raising the viscosity of the oral suspension, and in a flavored oral suspension by lowering the viscosity of the oral suspension.

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