Nanoparticulate ebastine formulations

Details Nanoparticulate ebastine formulations Nanoparticulate ebastine formulations

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 31/445 (2006.01)

Patent

CA 2611475

The invention is directed to compositions comprising at least one nanoparticulate H 1-histamine receptor antagonist, such as ebastine or a salt or derivative thereof, having improved dissolution rate providing a faster onset of drug availability. The nanoparticulate H1-histamine receptor antagonist particles, such as ebastine, have an effective average particle size of less than about 2000 nm and are useful in the treatment of seasonal and perennial allergic rhinitis and related diseases.

L'invention concerne des compositions comprenant au moins un antagoniste des récepteurs histaminergiques H1 nanoparticulaires, tel que l'ébastine ou un sel ou un dérivé de celle-ci, possédant une vitesse de dissolution améliorée permettant d'obtenir une disponibilité médicamenteuse plus rapide. Les particules de l'antagoniste des récepteurs histaminergiques H1 nanoparticulaires, tel que l'ébastine, possèdent une granulométrie moyenne efficace inférieure à environ 2000 nm et sont utiles dans le traitement de rhinites allergiques saisonnière et pérenniale et de maladies associées.

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