Cyclopropyl group substituted oxazolidinone antibiotics and...

Details Cyclopropyl group substituted oxazolidinone antibiotics and... Cyclopropyl group substituted oxazolidinone antibiotics and...

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/422 (2006.01) A61P 31/04 (2006.01) C07D 413/10 (2006.01) C07D 417/14 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2530140

This invention relates to new oxazolidinones having a cyclopropyl moiety, which are effective against aerobic and anerobic pathogens such as multi- resistant staphylococci, streptococci and enterococci, Bacteroides spp., Clostridia spp. species, as well as acid-fast organisms such as Mycobacterium tuberculosis and other mycobactenial species. The compounds are represented by structural formula: (I): its enantiomer, diastereomer, or pharmaceutically acceptable salt or ester thereof.

La présente invention concerne de nouvelles oxazolidinones représentées par la formule structurelle (I), ses énantiomères, diastéréomères, ou certains de leurs sels ou esters pharmaceutiquement admis. Ces nouvelles oxazolidinones, qui portent un groupe fonctionnel cyclopropyle, sont efficaces contre des gènes pathogènes aérobies et anaérobies tels que les staphylocoques, streptocoques et entérocoques multirésistants, les bactéroïdes, Clostridium, ainsi que les organismes résistant aux acides tels que Mycobacterium tuberculosis et autres mycobactéries.

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