A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 14/475 (2006.01) C07K 14/525 (2006.01) C07K 14/54 (2006.01) C07K 14/55 (2006.01) C07K 14/57 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01)
Patent
CA 2399866
Treatment of lesions of pathological angiogenesis, especially tumors, rheumatoid arthritis, diabetic retinopathy, age-related muscular degeneration, and angiomas. A conjugate is used comprising a molecule that exerts a biocidal or cytotoxic effect on target cells in the lesions and an antibody directed against an extracellular matrix component which is present in such lesions. The antibody may be directed against fibronectin-2 (IL-2), doxorubicin, interleukin-12(IL-12), Interferon-.gamma. (IFN-.gamma.), Tumor Necrosis Factor .alpha.(TNF.alpha.) or Tissue Factor protein (which may be truncated).
L'invention concerne le traitement de lésions de l'angiogénèse pathologique, notamment de tumeurs, de la polyarthrite rhumatoïde, de la rétinopathie diabétique, de la dégénérescence musculaire liée à l'âge, et d'angiomes. On utilise un conjugué comprenant une molécule exerçant un effet biocide ou cytotoxique sur des cellules cibles dans des lésions et un anticorps dirigé contre une composante de matrice extracellulaire présente dans ces lésions. L'anticorps peut être dirigé contre la fibronectine-2 (IL-2), la doxorubicine, l'interleukine-12 (IL-12), l'interféron-.gamma. (IFN-.gamma.), le facteur de nécrose tumorale .alpha.(TNF.alpha.) ou la protéine de facteur tissulaire (pouvant être tronquée).
Borsi Laura
Carnemolla Barbara
Halin Cornelia
Neri Dario
Nilsson Fredrik
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Philogen S.r.l.
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