A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/42 (2006.01) A61K 31/415 (2006.01)
Patent
CA 2592941
The invention relates to methods, compositions , and uses of those compositions for making medicaments, for potentiating the beneficial effects of inhibitors of COX-1, COX-2, and 5-LOX, and reducing adverse effects, by also administering inhibitors of soluble epoxide hydrolase ("sEH"), with or without also administering one or more cis-epoxyeicosantrienoic acids. The invention further relates to the use of inhibitors of sEH as analgesics and to methods and compositions of epoxides of eicosapentaenoic acid and docosahexaenoic acid to reduce pain or inflammation or both.
L'invention concerne des méthodes, des compositions et des utilisations de ces compositions pour fabriquer des médicaments destinés à potentialiser les effets bénéfiques d'inhibiteurs de COX-1, de COX-2 et de 5-LOX ainsi qu'à réduire les effets indésirables, également par administration d'inhibiteurs de l'époxyde hydrolase soluble (sEH) avec ou sans administration concomitante d'un ou plusieurs acides cis-époxyeicosatriénoïques. L'invention concerne également l'utilisation d'inhibiteurs de sEH comme analgésiques ainsi que des méthodes et des compositions d'époxydes d'acide eicosapentaénoïque et d'acide docosahexaénoïque destinées à réduire la douleur et/ou l'inflammation.
Hammock Bruce D.
Inceoglu Ahmet Bora
Schmelzer Kara
Borden Ladner Gervais Llp
Regents Of The University Of California
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