Indol-3-yl-carbonyl-spiro-piperidine derivatives

Details Indol-3-yl-carbonyl-spiro-piperidine derivatives Indol-3-yl-carbonyl-spiro-piperidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/10 (2006.01) A61K 31/438 (2006.01) A61P 9/02 (2006.01) C07D 498/10 (2006.01)

Patent

CA 2634120

This invention relates to indol -3-yl-carbonyl-spiro-piperidine derivatives which act as V1a receptor antagonists and which are represented by Formula (I) wherein the spiropiperidine-head group A and the residues R1, R2 and R3 are as defined herein. The invention further relates to pharmaceutical compositions containing such compounds, their use in medicaments against dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxiety and depressive disorders, and methods of preparation thereof.

La présente invention concerne des dérivés d'indol-3-yl-carbonyl-spiro-pipéridine en tant qu'antagonistes du récepteur V1a et représentés par la formule (I), le groupe de tête spiropipéridine A et les résidus R<SUP>1</SUP>, R<SUP>2</SUP> et R<SUP>3</SUP> étant tels que définis dans la présente invention. L'invention concerne également des compositions pharmaceutiques contenant de tels composés, leur utilisation dans des médicaments contre la dysménorrhée, l'hypertension, l'insuffisance cardiaque chronique, la sécrétion inappropriée de vasopressine, la cirrhose du foie, le syndrome néphrotique, les troubles obsessionnels compulsifs, l'anxiété et les troubles dépressifs, ainsi que des procédés de préparation desdites compositions.

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