Benzimidazole derivatives with antihistaminic activity

Details Benzimidazole derivatives with antihistaminic activity Benzimidazole derivatives with antihistaminic activity

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/445 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2206754

New benzimidazole derivatives of formula: (see formula I) in which R1 is H or a short chain hydrocarbon group such as methyl, ethyl, isopropyl, cyclopropyl, vinyl, etc., and R2 is a group selected from among the following: CH2OH, COOH, COOR3 and 4,4- dimethyl-2-oxazolinyl, R3 being a short chain alkyl group such as methyl, ethyl, etc., are described. A description is also made of the preparation of these compounds, which have a high H1 antihistaminic and antiallergic activity and are devoid of effects on the central nervous and cardiovascular systems.

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