Short duration depot formulations

Details Short duration depot formulations Short duration depot formulations

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01)

Patent

CA 2492047

Methods and compositions for systemically or locally administering by implantation a beneficial agent to a subject are described, and include, for example, depot gel compositions that can be injected into a desired location and which can provide controlled release of a beneficial agent over a short duration of time. The compositions include a low molecular weight biocompatible polymer, a biocompatible solvent having low water miscibility that forms a viscous gel with the polymer and limits water uptake by the implant, and a beneficial agent.

L'invention concerne des méthodes et des compositions destinées à être administrées de manière systémique ou locale, par implantation d'un agent bénéfique, dans un sujet. Les compositions sont, par exemple, des compositions de gel de dépôt pouvant être injectées à un emplacement désiré, et libérant de manière contrôlée un agent bénéfique sur une courte durée. Lesdites compositions comprennent un polymère biocompatible de faible poids moléculaire, un solvant biocompatible à faible miscibilité dans l'eau formant un gel visqueux avec le polymère et limitant l'absorption d'eau par un implant et un agent bénéfique.

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