Substituted indole derivatives

Details Substituted indole derivatives Substituted indole derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/454 (2006.01) A61P 25/04 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2716270

The present invention relates to substituted indole derivatives having the general formula (I) which act on the ORL 1 receptor wherein A and B mutually independently denote CH2, C=O or SO2, X stands for indolyl, unsubstituted or mono- or polysubstituted; T stands for (CR5a-c R6a-c)n, n = 1, 2 or 3, and Q stands for (CR7a-c R8a-c)m, m = 0,1, 2 or 3, processes for the preparation thereof, medicinal products containing these compounds and the use of substituted indole derivatives for the preparation of medicinal products.

La présente invention concerne des dérivés d'indole substitués de formule générale (I) qui agissent sur le récepteur ORL 1. Dans la formule, A et B représentent, indépendamment l'un de l'autre, CH2, C=O ou SO2, X représente un indolyle, non substitué ou mono- ou polysubstitué; T représente (CR5a-cR6a-c)n, n étant égal à 1, 2 ou 3, et Q représente (CR7a-cR6a-c)m, m étant égal à 0, 1, 2 ou 3. L'invention concerne également des procédés de préparation desdits dérivés d'indole substitués, des produits médicinaux en contenant et leur utilisation en vue de la préparation de produits médicinaux.

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