C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 15/79 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2543127
The invention provides and isolated squirrel monkey prokineticin receptor 2 (PKR2) polypeptide containing the amino acid sequence referenced as SEQ ID NO:2. The invention also provides an isolated chimpanzee PKR2 containing the amino acid sequence referenced as SEQ ID NO:4. Also provided are methods of identifying PKR2 agonists and antagonists using the squirrel monkey PKR2 polypeptide. Additionally, the invention provides an isolated rhesus monkey PK2 polypeptide containing the amino acid sequence referenced as SEQ ID NO:6. Nucleic acid molecules encoding the disclosed polypeptides further are provided by the invention.
L'invention concerne un polypeptide du récepteur 2 de la prokinéticine (PKR2) du singe-écureuil isolé contenant la séquence d'acides aminés référencée sous SEQ ID NO: 2. L'invention concerne également un PKR2 de chimpanzé isolé contenant la séquence d'acides aminés référencée sous SEQ ID NO: 4. Elle se rapporte en outre à des méthodes destinées à identifier des agonistes et des antagonistes de PKR2 au moyen du polypeptide du PKR2 du singe-écureuil. Par ailleurs, l'invention concerne un polypeptide de PK2 de singe rhésus isolé contenant la séquence d'acides aminés référencée sous SEQ ID NO: 6. Cette invention porte également sur des molécules d'acides nucléiques codant pour les polypeptides susmentionnés.
Osler Hoskin & Harcourt Llp
The Regents Of The University Of California
LandOfFree
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