Supramacromolecular polymer complexes providing controlled...

Details Supramacromolecular polymer complexes providing controlled... Supramacromolecular polymer complexes providing controlled...

C - Chemistry, Metallurgy

09

J

C09J 139/06 (2006.01) A61K 47/48 (2006.01) A61L 15/22 (2006.01) A61L 15/44 (2006.01) A61L 15/58 (2006.01) A61L 24/04 (2006.01) A61P 17/02 (2006.01) C08L 35/02 (2006.01) C08L 39/06 (2006.01) C09J 135/02 (2006.01)

Patent

CA 2599082

A bio-adhesive supramacromolecular complex of the general formula (I): (see formula I) wherein R1 is an alkane unsubstituted or substituted with alkoxy groups; R2 is a lower alkane; R3 and R4 are long chain, optionally substituted, alkanes; W is a hydrogen-bond accepting functional group-containing entity; Y is a carboxylic acid ester or amide; Z is a linking group; T1, T2, T3 and T4 are terminal groups; m and n are integers selected from at least 25; and wherein P has a molecular weight of about 1 × 10 3 to 1 × 10 6 and Q has a molecular weight of about 1 × 10 3 to 1 × 10 7. The complex provides controlled nitric oxide release over a longer period of time than prior art compounds in the healing of wounds and infections. Novel compositions, methods of preparation, skin coverings containing and medical use of the complexes are described.

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