Method of purifying tacrolimus

Details Method of purifying tacrolimus Method of purifying tacrolimus

C - Chemistry, Metallurgy

07

D

C07D 498/18 (2006.01) B01D 15/26 (2006.01)

Patent

CA 2586700

The invention provides pure tacrolimus and a method for purifying tacrolimus in which a loading charge of tacrolimus is placed in juxtaposition with a bed of wet sorption resin, the loading charge and bed are eluted with an eluent comprising THF, acetonitrile, or a combination thereof, water, and, optionally, at least one additional organic solvent, the heart cut of the eluent is collected, and tacrolimus is collected, the tacrolimus is further crystallized and recrystallized until obtaining a reduced level of impurities.

L'invention concerne du tacrolimus pur et un procédé de purification de celui-ci dans lequel une charge de tacrolimus est placée en juxtaposition avec un lit de résine de sorption humide, la charge et le lit étant élués au moyen d'un éluant comprenant THF, acétonitrile ou une combinaison de ceux-ci, de l'eau et éventuellement au moins un solvant organique supplémentaire, la fraction de coeur de l'éluant étant recueillie et le tacrolimus recueilli, puis cristallisé et recristallisé jusqu'à l'obtention d'un niveau réduit d'impuretés.

Affiliated with

Also associated with

Rating

Method of purifying tacrolimus does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of purifying tacrolimus, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of purifying tacrolimus will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1882312