Constitutive expression of costimulatory ligands on...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/078 (2010.01) C12N 5/0783 (2010.01) A01N 63/00 (2006.01) A61K 35/14 (2006.01) A61K 39/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2682527

The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing at least one of an antigen- recognizing receptor and a co-stimulatory ligand and methods of use therefore for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired.

La présente invention concerne des cellules immunosensibles, y compris des lymphocytes T, des lymphocytes T cytotoxiques, des lymphocytes T régulateurs, et des cellules tueuses naturelles (NK), exprimant au moins un récepteur reconnaissant un antigène et un ligand costimulant. L'invention concerne également des procédés d'utilisation de celles-ci dans le traitement de la néoplasie et d'autres pathologies dans lesquelles une augmentation de la réponse immunitaire spécifique à l'antigène est souhaitée.

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