C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/437 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2441926
Disclosed are compounds of the formula: (I), and the pharmaceuticallz acceptable salts thereof where the variables R1, R2, A, R4, R5, R6, R6', n, and W are defined herein. These compounds bind to the benzodiazepine site of GABAA receptors are provided and, therefore can be used to modulate ligand binding to GABAA receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals and livestock animals.
La présente invention concerne des composés de formule (I), et leurs sels pharmaceutiquement acceptables, formule dans laquelle les variables R¿1?, R¿2?, A, R¿4?, R¿5?, R¿6?, R¿6?', n et W sont tels que définis dans la description. Ces composés se lient au site de benzodiazépine des récepteurs GABA¿A? et, peuvent donc être utilisés pour la modulation du ligand se liant aux récepteurs de GABA¿A? in vivo ou in vitro, et sont particulièrement utiles dans le traitement de divers troubles du système nerveux central (SNC) chez l'homme, chez les animaux domestiques de compagnie et chez les animaux d'élevage.
Albaugh Pamela
Li Guiying
Peterson John M.
Neurogen Corporation
Osler Hoskin & Harcourt Llp
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